21 Results for "

Uncaria hirsutaHavil.

" in MedChemExpress (MCE) Product Catalog:
Products (21)

21 Results for "Uncaria hirsutaHavil." in MCE Product Catalog:

6
Corynoxeine
Corynoxeine
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6 Publications Verification
Cat. No.: HY-N0590
CAS No.: 630-94-4
Category:  

Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

ERK

Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
3
Corynoxine
Corynoxine
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3 Cited Publications
Cat. No.: HY-N0901
CAS No.: 6877-32-3
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

Autophagy

Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
2
Rhynchophylline
Rhynchophylline
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2 Cited Publications
Cat. No.: HY-N0387
CAS No.: 76-66-4
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Other Diseases Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

NF-κB

Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research. .
2
Hirsuteine
Hirsuteine
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2 Cited Publications
Cat. No.: HY-N2197
CAS No.: 35467-43-7
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Neurological Disease Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

nAChR

Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes .
1
Hirsutine
Hirsutine
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1 Cited Publications
Cat. No.: HY-N2193
CAS No.: 7729-23-9
Category:  

Infection Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

Flavivirus Dengue Virus Apoptosis

Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity .
1
Geissoschizine methyl ether
Geissoschizine methyl ether
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1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

5-HT Receptor

Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
Mitraphylline
Mitraphylline
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Cat. No.: HY-N6946
CAS No.: 509-80-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Rubiaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Interleukin Related

Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo .
Isopteropodine
Isopteropodine
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Cat. No.: HY-N4157
CAS No.: 5171-37-9
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Rubiaceae Plants

Target:  

mAChR 5-HT Receptor Bacterial

Isopteropodine is a positive modulator that selectively acts on muscarinic M1 and 5-HT2 receptors. Isopteropodine has an EC50 of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .
Uncarine F
Uncarine F
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Cat. No.: HY-N16467
CAS No.: 14019-66-0
Synonyms: Speciofiline
Category:  

Alkaloids Oxindole Alkaloids Rubiaceae Plants Mitragyna parvifolia (Roxb.) Korth.

Target:  

Others

Uncarine F (Speciofiline) is a pentacyclic oxindole alkaloid found in Uncaria tomentosa. Uncaria alkaloids have wide medicinal properties, including neuroprotective, anticancer, and antihypertensive activities. Uncaria alkaloids may stimulate the immune system, relax smooth muscles, dilate blood vessels, and act as a diuretic. Uncarine F can be used for the researches of cancer, immunology, cardiovascular and neurological disease .
Uncargenin C
Uncargenin C
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Cat. No.: HY-N1112
CAS No.: 152243-70-4
Category:  

Triterpenes Staphyleaceae Terpenoids Plants Turpinia arguta (Lindl.) Seem.

Target:  

Others

Uncargenin C is a triterpenoid, which can be isolated from Uncaria rhychophyllo Miq. Jacks. The intermediate of Uncargenin C has anti-leukemia activity, but not itself .
Mitraphylline (Standard)
Mitraphylline (Standard)
0 Images
Cat. No.: HY-N6946R
CAS No.: 509-80-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Rubiaceae Plants

Target:  

NF-κB Reference Standards Interleukin Related

Mitraphylline (Standard) is the analytical standard of Mitraphylline. This product is intended for research and analytical applications. Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo .
Corynoxine hydrochloride
Corynoxine hydrochloride
0 Images
Cat. No.: HY-N0901B
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

Autophagy

Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria macrophylla. Corynoxine hydrochloride is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid
3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid
0 Images
Cat. No.: HY-N1792
CAS No.: 91095-51-1
Category:  

Triterpenes Terpenoids Rubiaceae Uncaria sessilifructus Roxb. Plants

Target:  

Others

3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid is a Triterpenoids product that can be isolated from the herbs of Uncaria sessilifructus. .
Isopteropodine (Standard)
Isopteropodine (Standard)
0 Images
Cat. No.: HY-N4157R
CAS No.: 5171-37-9
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Rubiaceae Plants

Target:  

Reference Standards mAChR 5-HT Receptor Bacterial

Isopteropodine (Standard) is the analytical standard of Isopteropodine (HY-N4157). This product is intended for research and analytical applications. Isopteropodine is a positive modulator that selectively acts on muscarinic M1 and 5-HT2 receptors. Isopteropodine has an EC50 of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .
Isorhynchophylline (Standard)
Isorhynchophylline (Standard)
0 Images
Cat. No.: HY-N0766R
CAS No.: 6859-01-4
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

SOD Reference Standards

Isorhynchophylline (Standard) is the analytical standard of Isorhynchophylline. This product is intended for research and analytical applications. Isorhynchophylline is an alkaloid compound isolated from Uncaria. It can lower blood pressure, relax blood vessels, and protect nerves from damage caused by local ischemia.
3β, 19α-Dihydroxy-6-oxo-urs-12-en-23-al-28-oic acid
3β, 19α-Dihydroxy-6-oxo-urs-12-en-23-al-28-oic acid
0 Images
Cat. No.: HY-N1760
CAS No.: 261768-88-1
Category:  

Uncaria tomentosa (Willd. ex Schult.) DC. Triterpenes Terpenoids Rubiaceae Plants

Target:  

Others

3β, 19α-Dihydroxy-6-oxo-urs-12-en-23-al-28-oic acid (compound 1) is a triterpene that can be isolated from Uncaria .
Corynoxeine (Standard)
Corynoxeine (Standard)
0 Images
Cat. No.: HY-N0590R
CAS No.: 630-94-4
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

Reference Standards ERK

Corynoxeine (Standard) is the analytical standard of Corynoxeine. This product is intended for research and analytical applications. Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
Rhynchophylline (Standard)
Rhynchophylline (Standard)
0 Images
Cat. No.: HY-N0387R
CAS No.: 76-66-4
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

Reference Standards NF-κB

Rhynchophylline (Standard) is the analytical standard of Rhynchophylline. This product is intended for research and analytical applications. Rhyncholphylline is an alkaloid compound isolated from Uncaria rhynchophyllum. Rhyncholphylline is an EphA4 inhibitor. It has high biological activity and is widely used in anti-inflammatory, neuroprotective and other research. .
Quinovic acid 3-O-(6-deoxy-β-D-glucopyranoside) 28-O-β-D-glucopyranosyl ester
Quinovic acid 3-O-(6-deoxy-β-D-glucopyranoside) 28-O-β-D-glucopyranosyl ester
0 Images
Cat. No.: HY-N1525
CAS No.: 124727-10-2
Category:  

Uncaria tomentosa (Willd. ex Schult.) DC. Triterpenes Terpenoids Rubiaceae Plants

Target:  

Others

Quinovic acid 3-O-(6-deoxy-β-D-glucopyranoside) 28-O-β-D-glucopyranosyl ester is a Triterpenoids product that can be isolated from the vines of Uncaria tomentosa .
3,6,19-Trihydroxy-23-oxo-12-ursen-28-oic acid
3,6,19-Trihydroxy-23-oxo-12-ursen-28-oic acid
0 Images
Cat. No.: HY-N1793
CAS No.: 131984-82-2
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Triterpenes Terpenoids Rubiaceae Plants

Target:  

Others

3,6,19-Trihydroxy-23-oxo-12-ursen-28-oic acid is a Triterpenoids product that can be isolated from the vines of Uncaria rhynchophylla .
Assay Types